期刊
ORGANIC LETTERS
卷 21, 期 9, 页码 3436-3440出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b01212
关键词
-
资金
- National Natural Science Foundation of China [21362022]
An effective approach to realize the direct hydroxyalkylation of imidazo[1,2-a]pyridines with alcohols promoted by di-tert-butyl peroxide was described without any metal catalyst. It is the first time that the dehydrogenative C(sp(3))-C(sp(2)) coupling of imidazo[1,2-a]pyridines with alcohols occurred regioselectively at the C-5 position of imidazo[1,2-a]pyridines. Multisubstituted imidazopyridine derivatives were smoothly synthesized in moderate to good yields. Through a series of control experiments, a free-radical pathway was proposed to explain the experiment.
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