期刊
ORGANIC LETTERS
卷 21, 期 9, 页码 3247-3251出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00976
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资金
- KAKENHI [26410111]
- Grants-in-Aid for Scientific Research [26410111] Funding Source: KAKEN
Investigation of the copper-catalyzed coupling reaction of 2-pyridinesulfonates with Grignard reagents revealed that reactions with catalytic Cu(OTf)(2) were completed in <40 min. The results differed from those of the previous CuI-catalyzed reactions of tosylates in the presence of additives (LiOMe and TMEDA) for 12-24 h. It was shown that the preferred coordination of the leaving group to the reagents accelerated the reaction. Successful reagents were MeMgCl and other RMgX. Complete inversion was established.
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