4.8 Article

Nickel-Catalyzed Intramolecular Direct Arylation of lmines toward Diverse Indoles

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ORGANIC LETTERS
卷 21, 期 9, 页码 3053-3056

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00600

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  1. National Science Foundation of China [21702035]
  2. GDUPS
  3. Science and Technology Program of Guangzhou [201804010455]

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An efficient nickel-catalyzed intramolecular direct arylation of imines with challenging aryl chlorides has been developed. The versatile nickel catalysis made use of easily accessible imines and delivered diversely decorated 2-arylindoles of considerable importance to biological and medicinal chemistry.

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