期刊
ORGANIC LETTERS
卷 21, 期 8, 页码 2790-2794出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b00749
关键词
-
资金
- Natural Science Foundation of Jiangsu Province [BK20160396]
A chiral Bronsted acid catalyzed highly enantio- and diastereoselective cascade cyclization has been developed to streamline the synthesis of valuable multifunctionalized enantioenriched cyclopenta[f]pyrrolo[1,2-d][1,4]diazepinones bearing three contiguous stereocenters in high yields with excellent control of stereochemistry from a wide range of both readily available 2-furylcarbinols and (1H-pyrrol-1-yl)anilines, which represents the first asymmetric intramolecular conjugate addition of alpha,beta-unsaturated cycloketones with inert N-substituted pyrroles as well as the first enantioselective aza-piancatelli rearrangement/Friedel-Crafts alkylation cascade reaction.
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