期刊
ORAL DISEASES
卷 26, 期 4, 页码 719-732出版社
WILEY
DOI: 10.1111/odi.13115
关键词
histone modifications; histone-modifying enzymes; inhibitors; malignant transformation; oral potentially malignant disorders; oral squamous cell carcinoma
资金
- National Natural Science Foundations of China [81500855, 81520108009, 81572663, 81621062, 81472533, 81771081]
- 111 Project of MOE China [B14038]
- Open Foundation from the State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University [SKLOD2016OF01]
Oral squamous cell carcinoma (OSCC) is a common malignancy with dismal prognosis without effective therapeutic options in advanced cases. The evolution from oral potentially malignant disorders to OSCC has poorly described underlying epigenetic features. With the ability of silencing or activation of vital genes, histone modifications' and modifiers' potentiality for early diagnosis, prognosis predicting, and therapy in OSCC were evaluated by extensive epigenetic studies. This review investigates the roles of dysregulated histone modifications and the associated modifying enzymes in OSCC onset and progression. Also, we focus on the current advances of histone modifications as therapeutic targets and the potential value of epi-drugs.
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