期刊
OPTIMAL CONTROL APPLICATIONS & METHODS
卷 40, 期 4, 页码 703-727出版社
WILEY
DOI: 10.1002/oca.2507
关键词
cholera; coinfection; numerical results; Pontryagin's maximum principle; schistosomiasis
The present work investigates the coinfection dynamics of the cholera and schistosomiasis diseases. The steady states of the model are examined. We obtain results for the model in detail and present the stability results whenever the basic reproduction number is less than unity (R0<1). For each submodel, the existence of backward bifurcation is presented and for the coinfection model. Furthermore, we formulate an optimal control problem with an appropriate set of control variables. The optimal control problem and the associated results are derived and discussed. The optimal control problem and the suggested controls are utilized to obtain optimal control characterizations. Numerical results are presented by choosing various optimal control strategies for the early elimination of both infections from the population. It is suggested that appropriate uses and application to the population could significantly reduce the infection. Therefore, based on our findings, we suggest to the public health department that the only possible cost-effective strategy for the elimination of schistosomiasis and cholera coinfection is the combination of both diseases' preventive measures and the treatment of schistosomiasis.
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