期刊
NUCLEIC ACIDS RESEARCH
卷 47, 期 11, 页码 5480-5489出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkz277
关键词
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资金
- Carlos III Program of Health [Pl17/00380]
- Department of Health, Pais Vasco [2018111043, 2018222031]
- Medical Research Foundation
- BBSRC [BB/F012802/1] Funding Source: UKRI
- MRC [MC_U105663140] Funding Source: UKRI
The DNA in mitochondria contributes essential components of the organelle's energy producing machinery that is essential for life. In 1971, many mitochondrial DNA molecules were found to have a third strand of DNA that maps to a region containing critical regulatory elements for transcription and replication. Forty-five years later, a third strand of RNA in the same region has been reported. This mitochondrial R-loop is present on thousands of copies of mitochondrial DNA per cell making it potentially the most abundant R-loop in nature. Here, I assess the discovery of the mitochondrial R-loop, discuss why it remained unrecognized for almost half a century and propose for it central roles in the replication, organization and expression of mitochondrial DNA, which if compromised can lead to disease states.
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