期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 100, 期 -, 页码 9-18出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2019.02.009
关键词
ADHD; Zebrafish; Behavior; Genetics; Dopamine; Noradrenaline; Serotonin
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- British Academy (BA)
- Foundation for Liver Research (UK)
- CNPq [307595/2015-3]
- PROEX/CAPES fellowship grant [23038.005848/2018-31, 0737/2018]
- Russian Foundation for Basic Research (RFBR) [16-04-00851]
Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Dario rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing animal models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.
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