期刊
NEUROREPORT
卷 30, 期 6, 页码 428-433出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000001220
关键词
chronic periodontitis; ischemic stroke; neuroinflammation
资金
- Guangdong provincial science and technology plan project [2017A040406007, 2016B030230002, 2014B040404053]
- Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases [2017B030314103]
- Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases [2015B050501003]
- Guangzhou Clinical Research and Translational Center for Major Neurological Diseases [201604020010]
- Guangdong Provincial Engineering Center for Major Neurological Disease Treatment
- National Natural Science Foundation of China [81371255, 81671102]
- National Key Research and Development Program of China, Stem Cell and Translational Research [2017YFA0105104]
- Guangzhou Science and Technology [201605030012]
Ischemic stroke is a common life-threatening disease. Epidemiological studies have shown that chronic periodontitis is closely related to ischemic stroke. However, it remains unknown whether periodontitis plays a direct role in the injury of cerebral ischemia. To explore the role of chronic periodontitis in the development process of ischemic stroke, we combined two mouse models: experimental periodontitis induced by a periodontal injection of lipopolysaccharide and ischemic stroke induced by the photothrombotic method. Alveolar bone loss and inflammatory infiltration of the periodontal tissue were found in the mice with experimental periodontitis. Periodontitis significantly increased the infarction volume, and numbers of activated microglia and astrocytes. Furthermore, an increased expression of nod-like receptor protein 3 inflammasome and interleukin-1 beta was detected in the peri-infarct region. We drew a conclusion that chronic periodontitis exacerbated ischemic stroke by increasing the activation of microglia/astrocytes and the expression of nod-like receptor protein 3 inflammasome and interleukin-1 beta. This suggested that chronic periodontitis played a role in ischemic brain injury directly through exacerbating the inflammation of the damaged brain.
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