期刊
NEUROREPORT
卷 30, 期 6, 页码 434-440出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000001223
关键词
Alzheimer's disease; EGb 761; neuroinflammatory response; nuclear factor-kappa B; P38 MAPK
Ginkgo biloba extract EGb 761 possesses a variety of biological effects and has been proved to be beneficial in Alzheimer's disease. This study aimed to explore the anti-inflammatory mechanisms of EGb 761 on the A beta(1-42)-induced BV-2 microglial cells. We analyzed the production and gene expression of proinflammatory cytokines by enzyme-linked immunosorbent assay and qRT-PCR, examined phosphorylation of MAPKs by western blot and measured nuclear factor-kappa B nuclear translocation. Compared with A beta(1-42)-treated group, EGb 761 inhibited release and gene expression of tumor necrosis factor-alpha and interleukin-1 beta, suppressed nuclear translocation of nuclear factor-kappa B and attenuated phosphorylation of p38 MAPK in a concentration-dependent manner, but not ERK and JNK. In summary, the results suggested that EGb 761 could attenuate A beta(1-42)-induced neuroinflammatory response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据