期刊
NEURON
卷 102, 期 4, 页码 735-744出版社
CELL PRESS
DOI: 10.1016/j.neuron.2019.03.027
关键词
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资金
- European Union [604102, 720270, 785907, 754304]
- Research Council of Norway [DigiBrain 248828, CoBra 250128]
- Deutsche Forschungsgemeinschaft [GR 1753/4-2, DE 2175/2-1, SPP 1665]
- Helmholtz Association Initiative and Networking Fund [ZT-I-0003, SO-902]
- VSR Computation Time Grant Brain-Scale Simulations [JINB33]
- Swiss ETH Domain
- [RTG 2416]
A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by comparison with experiments, the simulations should be multimodal in the sense that they should predict not only action potentials, but also electric, magnetic, and optical signals measured at the population and system levels.
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