期刊
NEUROBIOLOGY OF AGING
卷 83, 期 -, 页码 150-154出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2019.04.013
关键词
Reserve; Resilience; Novel approaches; Epigenetics; Regeneration; Intervention
资金
- McKnight Brain Research Foundation
- National Institutes of Health [P50 AG005146, U19 AG033655, P30 AG050886, R01 AG043972, R01 AG051807, R21 AG050787, R01 AG055797, R01 AG049002, R01 AG0048908]
- US National Institutes of Health Biobehavioral Research Awards for Innovative New Scientists (BRAINS) [R01 MH104175]
- Ellison Medical Foundation New Scholar in Aging
- Whitehall Foundation
- Ellison Family Philanthropic
Novel approaches to address cognitive aging and to delay or prevent cognitive decline in older individuals will require a better understanding of the biological and environmental factors that contribute to it. Studies in animal models-in particular, animals whose cognitive trajectory across their life span closely tracks that of humans-can provide important insights into the factors that contribute to the accumulation of reserve and ways in which it is preserved or depleted. A better understanding of the molecular processes that underlie these elements would enhance and guide not only research but also treatment approaches to these issues. These treatment approaches may include noninvasive brain stimulation and drug treatments to promote youthfulness or combat the aging process. It is important to realize, however, that these processes occur in the context of the human experience, and studies of them must consider the complexity and individuality of each person's life. (C) 2019 Published by Elsevier Inc.
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