期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 26, 期 5, 页码 331-334出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41594-019-0223-0
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资金
- EMBL grant [50800]
- EMBL fellowship
- Rett Syndrome Research Trust (RSRT) grant
- European Research Council [RIBOMYLOME_309545]
- Spanish Ministry of Economy, Industry, and Competitiveness [BFU2014-55054-P, BFU2017-86970-P]
- Fundacio La Marato de TV3 [PI043296]
- Caltech grant
- Spanish Ministry of Economy, Industry and Competitiveness (MEIC)
- Centro de Excelencia Severo Ochoa
- CERCA Programme/Generalitat de Catalunya
The long non-coding RNA Xist induces heterochromatinization of the X chromosome by recruiting repressive protein complexes to chromatin. Here we gather evidence, from the literature and from computational analyses, showing that Xist assemblies are similar in size, shape and composition to phase-separated condensates, such as paraspeckles and stress granules. Given the progressive sequestration of Xist's binding partners during X-chromosome inactivation, we formulate the hypothesis that Xist uses phase separation to perform its function.
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