期刊
NATURE PHYSICS
卷 15, 期 8, 页码 839-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41567-019-0516-6
关键词
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资金
- Rosetrees Trust
- UCL Graduate School
- EPSRC
- European Research Council (ERC-CoG MolCellTissMech) [647186]
- UCL Overseas Research Scholarship
- Professor Rob Seymour Travel Bursary Fund
- BBSRC [BB/K013521, BB/K018175/1, BB/M003280, BB/M002578, BB/K009001/1]
- Ministry of Economy, Industry and Competitiveness [DPI2013-43727R, DPI2016-74929-R]
- Generalitat de Catalunya [2014-SGR-1471]
- Universitat Politecnica de Catalunya [UPC-FPI 2012]
- Consorci Escola Industrial de Barcelona [UPC-FPI 2012]
- European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013)/ERC [240487]
- European Molecular and Biology Organization [ASTF 351-2016]
- Marie Sklodowska-Curie Horizon 2020 Individual Fellowship (MRTGS)
- HFSP Young Investigator award [RGY 66/2013]
- Japan Society for the Promotion of Science [26114001, 18H03994]
- Strategic Japanese-Swiss Science and Technology Programme, AMED [JP17ck0106361, JP18cm0106234]
- SAN-ESU GIKEN Co. Ltd
- Naito Foundation
- Takeda Science Foundation
- MRC [MR/L009056/1]
- UCL Excellence Fellowship
- NSFC International Young Scientist Fellowship [31650110472]
- UCL
- CRUK programme [17343]
- EPSRC [EP/K038656/1]
- European Research Council (ERC) [647186] Funding Source: European Research Council (ERC)
- Grants-in-Aid for Scientific Research [26114001, 18H03994] Funding Source: KAKEN
- BBSRC [BB/K013521/1, BB/K009001/1, BB/K013696/1, BB/R000042/1, BB/K018175/1, BB/J008532/1, BB/M003280/1, BB/M002578/1] Funding Source: UKRI
- EPSRC [EP/K038656/1] Funding Source: UKRI
- MRC [MR/L009056/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K009001/1, BB/J008532/1] Funding Source: researchfish
- Cancer Research UK [23335] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K038656/1] Funding Source: researchfish
- Medical Research Council [MR/L009056/1] Funding Source: researchfish
Epithelial monolayers are one-cell-thick tissue sheets that line most of the body surfaces, separating internal and external environments. As part of their function, they must withstand extrinsic mechanical stresses applied at high strain rates. However, little is known about how monolayers respond to mechanical deformations. Here, by subjecting suspended epithelial monolayers to stretch, we find that they dissipate stresses on a minute timescale and that relaxation can be described by a power law with an exponential cut-off at timescales larger than about 10s. This process involves an increase in monolayer length, pointing to active remodelling of cellular biopolymers at the molecular scale during relaxation. Strikingly, monolayers consisting of tens of thousands of cells relax stress with similar dynamics to single rounded cells, and both respond similarly to perturbations of the actomyosin cytoskeleton. By contrast, cell-cell junctional complexes and intermediate filaments do not relax tissue stress, but form stable connections between cells, allowing monolayers to behave rheologically as single cells. Taken together, our data show that actomyosin dynamics governs the rheological properties of epithelial monolayers, dissipating applied stresses and enabling changes in monolayer length.
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