期刊
NATURE NEUROSCIENCE
卷 22, 期 5, 页码 770-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41593-019-0376-5
关键词
-
资金
- Japan Society for the Promotion of Science [18J12572]
- MEXT [15H03123, 17H06062]
- Keio University
- Grants-in-Aid for Scientific Research [17H06062, 18J12572, 15H03123] Funding Source: KAKEN
The ability to sustain goal-directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-directed behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-directed behavior. Suppression of vHP during sustained goal-directed behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-directed behavior. Sustainment of goal-directed action may require suppression of vHP because of the structure's well-documented role in behavioral inhibition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据