期刊
NATURE GENETICS
卷 51, 期 5, 页码 793-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-019-0397-8
关键词
-
资金
- US National Institute of Mental Health
- Brain and Behavior Research Foundation
- Stanley Medical Research Institute
- University of Michigan
- Pritzker Neuropsychiatric Disorders Research Fund L.L.C.
- Marriot Foundation
- Mayo Clinic Center for Individualized Medicine
- NIMH Intramural Research Program
- Canadian Institutes of Health Research
- UK Maudsley NHS Foundation Trust
- NIHR
- NRS
- MRC
- Wellcome Trust
- European Research Council
- German Ministry for Education and Research
- German Research Foundation IZKF of Munster
- Deutsche Forschungsgemeinschaft
- ImmunoSensation
- Dr Lisa-Oehler Foundation
- University of Bonn
- Swiss National Science Foundation
- French Foundation FondaMental
- French ANR
- Spanish Ministerio de Economia
- CIBERSAM
- Industria y Competitividad
- European Regional Development Fund (ERDF)
- Generalitat de Catalunya
- EU Horizon 2020 Research and Innovation Programme
- BBMRI-NL
- South-East Norway Regional Health Authority
- Swedish Research Council
- Stockholm County Council
- Soderstrom Foundation
- Lundbeck Foundation
- Aarhus University
- Australia NHMRC
- NSW Ministry of Health
- MRC [UKDRI-3003, MR/L023784/2] Funding Source: UKRI
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 x 10(-4) in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 x 10(-8)) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据