Triterpenoids from the fresh pericarps of Juglans hopeiensis

Two new triterpenoids (1-2), jughopanes A (1) and jughopanes B (2), along with seventeen known ones (3-19), were isolated from the fresh pericarps of Juglans hopeiensis Hu. Their structures were settled by integrated spectroscopic techniques. All isolates were tested for their cytotoxic activities and the results showed that 7 exhibited moderate cytotoxicities against MCF7 and HT29 cancer cell lines with IC50 values of 5.24 and 6.01 mu M, respectively.

Automated summary

Two new triterpenoids, jughopanes A and jughopanes B, along with seventeen known ones were isolated from the fresh pericarps of Juglans hopeiensis. Compound 7 showed moderate cytotoxicity against MCF7 and HT29 cancer cell lines, indicating its potential as an anticancer agent.