Syn-2, 3-diols and anti-inflammatory indole derivatives from Streptomyces sp. CB09001

Two new natural diols, (2S, 3S, 4S)-4-methyl-1-phenylhexane-2,3-diol (1) and (2S, 3S)-4-methyl-1-phenylpentane-2,3-diol (2), together with five known compounds, xenocyloins B-D (3-5), lumichrome (6) and thymidine (7) were isolated from Streptomyces sp. CB09001. The absolute configurations of 1 and 2 were established by crystallographic structure analysis. The anti-inflammatory effects of 1-7 were also investigated in RAW246.7 murine macrophage cells stimulated by lipopolysaccharide. The indole derivative xenocyloin B (3) significantly inhibited inducible nitric oxide synthase expression in RAW264.7 cells and could be a potential anti-inflammatory drug lead.

Automated summary

Two new natural diols and five known compounds were isolated from Streptomyces sp. CB09001, with their absolute configurations established by crystallographic structure analysis. One of the compounds showed significant inhibition of inducible nitric oxide synthase expression in macrophage cells and could be a potential lead for anti-inflammatory drug development.