期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 5, 页码 819-821出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1598992
关键词
Eucalyptus globulus; blood pressure; antihypertensive; vasorelaxation; L-NAME; nitric oxide
资金
- CNRST [PPR/2015/35]
The study demonstrates that the aqueous extract of Eucalyptus globulus leaves can reduce blood pressure in hypertensive rats by activating nitric oxide production to relax aortic rings. Furthermore, AEEG shows potential as an antihypertensive agent to reduce the burden of cardiovascular complications.
In the current study we determined the effect of the aqueous extract of leaves of Eucalyptus globulus (AEEG) in anesthetized normal and L-NAME-induced hypertensive rats and on rings of isolated thoracic aorta from Wistar rats at a dose of 160 mg/kg. Our results show that AEEG extract reduced systolic, mean and diastolic blood pressure after repeated (7 days) oral administration of this extract in hypertensive rats. In addition, it was revealed from the present study that AEEG relaxed aortic rings in a dose-dependent (25-200 mu g/ml) manner via the activation of nitric oxide production. Pre-treatment of aortic rings with indomethacin, glibenclamide, nifedipine or propranolol did not attenuate the AEEG-induced vasorelaxation. Our data elucidate the health-orientated virtues of using AEEG which may play an important role as an antihypertensive agent to reduce the burden of cardiovascular complications.
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