期刊
NATURAL PRODUCT RESEARCH
卷 34, 期 20, 页码 2880-2886出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1596099
关键词
Sponge-derived fungus; Penicillium chrysogenum; sorbicillinoid; trisorbicillinone
资金
- National Key Research and Development Program of China [2018YFC0310900]
- National Natural Science Fund of China [U1605221]
- Shanghai Municipal Health Commission excellent young talent program [2018YQ28]
- Sichuan Science and Technology Program [2018JZ0017]
Two new sorbicillinoids, 13-hydroxy-dihydrotrichodermolide (1) and 10,11,27,28-tetrahydrotrisorbicillinone C (2), were isolated from the sponge-derived fungus Penicillium chrysogenum 581F1. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 2 displayed high affinities to target proteins GLP-1R (diabetes) and eEF2K (cancer) with K-d values of 0.0285 mu M, 0.0162 mu M for GLP-1R and 0.118 mu M, 0.0746 mu M for eEF2K, respectively. [GRAPHICS] .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据