期刊
NANOMEDICINE
卷 14, 期 10, 页码 1291-1306出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0390
关键词
4T1 tumor; cancer immunotherapy; dendritic cells; immunoactive polysaccharide; memory T cells; nanomaterial; pulmonary metastasis
资金
- National Key Research and Development Program of China [2016YFC0101200]
- National Natural Science Foundation of China [81373950, 51503139, 31771104]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection
Aim: To investigate the immune responses and antitumor efficacy of immunoactive polysaccharide functionalized gold nanocomposites (APS-AuNP). Materials & methods: Immunoregulation of APS-AuNP on dendritic cells/T cells in vitro was evaluated by flow cytometry and their inhibitions against primary/metastatic tumors were determined on 4T1-bearing mice model. Results & conclusion: APS-AuNP exhibited remarkable capability to induce dendritic cells maturation through phenotypic markers with functional changes, which further promoted T-cell proliferation and enhanced cytotoxicity against 4T1 tumor cells. The inhibitory rate of APS-AuNP against 4T1 primary tumor growth and pulmonary metastasis in mice was higher than paclitaxel-treated group. In addition, APS-AuNP exhibited strong capability to increase the population of CD4(+)/CD8(+) T lymphocytes as well as effector memory cells rather than central memory cells.
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