期刊
NANO LETTERS
卷 19, 期 6, 页码 4180-4187出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b01727
关键词
Tissue-like electronics; ultrasmall needle; minimal footprint; ultraflexible probe; one-dimensional probe; soft material integration
类别
资金
- National Institutes of Health Director's Pioneer Award [1DP1EB025835-01]
- Air Force Office of Scientific Research [FA9550-14-1-0136]
- Harvard University Physical Sciences and Engineering Accelerator award
- Cutting Edge Basic Research Award under National Institutes of Health/National Institute on Drug Abuse Grant [3R21DA043985-02S1]
- National Science Foundation Graduate Research Fellowship Program [DGE1144152, DGE1745303]
- American Heart Association [16POST27250219]
- National Institutes of Health Pathway to Independence Award from the National Institute on Aging [1K99AG056636-01]
- National Science Foundation
The unique structure and mechanical properties of syringe-injectable mesh electronics have enabled seamless tissue integration and stable chronic recording of the activities of the same neurons on a year scale. Here, we report studies of a series of structural and mechanical mesh electronics design variations that allow injection using needles at least 4-fold smaller than those previously reported to minimize the footprint during injection of the electronics in soft matter and tissue. Characterization of new ultraflexible two-dimensional (2D) and one-dimensional (1D) probes has demonstrated reproducible injection of the newly developed mesh electronics designs via needles as small as 100 mu m in inner diameter (ID) with reduced injection volumes. In vitro hydrogel and in vivo mouse brain studies have shown that ultraflexible 2D and 1D probes maintain their structural integrity and conformation post-injection after being transferred through the reduced diameter needles. In addition, analysis of the variation of the post-injection mesh cross sections suggests a smaller degree of tissue deformation and relaxation with decreasing needle diameters. The capability to implement rational design for mesh electronic probes that can be delivered via much smaller diameter needles should open up new opportunities for integration of electronics with tissue and soft matter in fundamental and translational studies.
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