期刊
MOLECULES
卷 24, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules24081617
关键词
anticonvulsant; Baldrinal; pilocarpine; neuroprotective; neurotransmitter; -aminobutyric acid; astrocytes
资金
- Ningxia Hui Autonomous Region science and technology support program [2015BAK45B01]
- major construction programs of Ningxia Medical University [XY201713]
- Ningxia Hui Autonomous Region Key Research and Development research [2017BY079]
- Ningxia 13th Plan of 5-year major scientific program [2016BZ 07]
Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of the epileptic patients that suffer from seizures do not receive effective medical treatment. The aim of this study was to determine the potential anticonvulsant activities of Baldrinal (BAL) with a mouse model of pilocarpine (PILO)-induced epilepsy. The mice were treated with different doses of BAL or sodium valproate prior to PILO injection. Spontaneous and evoked seizures were evaluated from EEG recordings, and their severity was tested by the Racine scale. In addition, the brain tissues were analyzed for histological changes, and the in situ levels of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) were also measured. Activation of astrocytes in the hippocampus was measured. PILO-treated mice showed a significant increase in Glu levels, which was restored by BAL. In addition, BAL treatment also reduced the rate of seizures in the epileptic mice, and ameliorated the increased levels of NMDAR(1), BDNF, IL-1 and TNF-. Taken together, BAL has a potential antiepileptic effect, which may be mediated by reducing the inflammatory response in the PILO-induced brain and restoring the balance of GABAergic and glutamatergic neurons.
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