期刊
MOLECULES
卷 24, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/molecules24112051
关键词
Coumarin; pyrazole; hydrazone; MRSA; drug-resistant; Acinetobacter baumannii; antimicrobials; ESKAPE pathogen; Staphylococcus aureus
资金
- National Institute of General Medical Sciences, (NIGMS) from the National Institutes of Health [P20 GM103429, P20 GM109005]
- VA Merit Review grant [2IO1BX002425]
- ABI [P20 GM109005, 200136]
Microbial resistance to drugs is an unresolved global concern, which is present in every country. Developing new antibiotics is one of the guidelines of the Centers for Disease Control and Preventions (CDC) to combat bacterial resistance to drugs. Based on our lead molecules, we report the synthesis and antimicrobial studies of 27 new pyrazole derivatives. These new coumarin-pyrazole-hydrazone hybrids are readily synthesized from commercially available starting materials and reagents using benign reaction conditions. All the synthesized molecules were tested against 14 Gram-positive and Gram-negative bacterial strains. Several of these molecules have been found to be potent growth inhibitors of several strains of these tested bacteria with minimum inhibitory concentrations as low as 1.56 g/mL. Furthermore, active molecules are non-toxic in in vitro and in vivo toxicity studies.
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