期刊
MOLECULAR PSYCHIATRY
卷 25, 期 6, 页码 1286-1300出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41380-019-0408-2
关键词
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资金
- Intramural Research Program of the NIH, National Institute on Aging
- NATIONAL INSTITUTE ON AGING [ZIAAG000513] Funding Source: NIH RePORTER
Systemic inflammation may influence trajectories of depressive symptoms over time, perhaps differentially by sex and race. Inflammatory markers and the Center for Epidemiologic Studies-Depression scale [total score: CES-D-total and four distinctive domains: somatic complaints, depressed affect, positive affect and interpersonal problems] were examined among African-American (AA) and White urban adults participating in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study [2004-2013, Age(base):30-64 y, mean +/- SD follow-up time: 4.64 +/- 0.93 y, N = 150 (with cytokine data) to N = 1,767 (with other inflammatory markers)]. Findings suggest that serum concentrations of high-sensitivity C-reactive protein (hsCRP), z-inflammation composite score [ICS, combining elevated hsCRP and ESR with low serum albumin and iron], and serum interleukin (IL) 1 beta were positively associated with Delta CES-D-total (Delta: annual rate of increase) among Whites only. IL-12 was directly related to Delta CES-D-total among men and AA. The race-specific associations of hsCRP, ICS, IL-1 beta and the sex-specific association of IL-12 with Delta CES-D-total were replicated for the depressed affect domain. Similarly, among men, lower serum albumin and higher ICS were linked with higher baseline somatic complaints. IL-10 among AA and IL-12 among men were inversely related to Deltapositive affect, while interpersonal problems were cross-sectionally associated with IL-6 among AA and IL-10 among Whites. Finally, baseline ICS was positively associated with incident elevated depressive symptoms (EDS: CES-D-total >= 16) among AA (HR = 1.28, 95% CI: 1.04-1.56, P = 0.017). Overall, systemic inflammation was directly linked to increased depressive symptoms over time and at baseline, differentially across sex and race groups. More longitudinal research is needed to replicate our findings.
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