期刊
MOLECULAR PHARMACEUTICS
卷 16, 期 5, 页码 2249-2258出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.9b00261
关键词
tumor-associated macrophages; tumor immunotherapy; nanoparticles; zoledronate; pH sensitive
资金
- National Natural Science Foundation of China [81573370, 81872820]
Tumor-associated macrophages (TAMs) are recruited from circulatory monocytes by tumor-derived factors, which differentiate into macrophages residing in the tumor microenvironment. TAMs play critical roles in promoting angiogenesis, invasion, metastasis and immune escape, and the direct depletion of TAMS is a promising strategy for tumor immunotherapy. In this study, we developed lipidcoated calcium zoledronate nanoparticles (CaZol@pMNPs) containing conjugated mannose, which were sterically shielded with an extracellular pH-sensitive material. The NPs specifically targeted TAMs and induced their apoptosis in vitro and in vivo. In a S180 tumor-bearing mouse model, CaZol@pMNPs effectively depleted TAMs, markedly decreased angiogenesis, reduced immune suppression, and eventually restrained tumor growth without eliciting systemic effects. The collective data indicate the potential of the direct depletion of TAMs using CaZol@pMNPs for cancer immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据