Facile, efficient and one-pot access to diverse new functionalized aminoalkyl and amidoalkyl naphthol scaffolds via green multicomponent reaction using triethylammonium hydrogen sulfate ([Et3NH][HSO4]) as an acidic ionic liquid under solvent-free conditions

An efficient, clean and one-pot multicomponent synthesis of divers kind of new functionalized aminoalkyl naphthol and amidoalkyl naphthol derivatives via tandem condensation reaction of 2-naphthol, aromatic aldehydes and 5-methyl-1,3,4-thiadiazol-2-amine/5-aryl-1,3,4-thiadiazol-2-amines urea/acetamide under solvent-free conditions is reported. Following this protocol, it was possible to synthesize novel 1-(((5-methyl-1,3,4-thiadiazol-2-yl)amino)(aryl)methyl)naphthalen-2-ol, 1-(aryl((5-aryl-1,3,4-thiadiazol-2-yl)amino)methyl)naphthalen-2-ol and amidoalkyl naphthol derivatives. This protocol includes some salient features, such as the use of triethylammonium hydrogen sulfate ([Et3NH][HSO4]) ionic liquid as a green, clean and reusable catalyst, no column chromatographic separation, high atom economy, good yields, low cost and finally no need for a complex procedure. [GRAPHICS] .