期刊
MOLECULAR CARCINOGENESIS
卷 58, 期 8, 页码 1389-1399出版社
WILEY
DOI: 10.1002/mc.23022
关键词
exosome; hepatocellular carcinoma; p120-catenin; STAT3
资金
- Natural Science Foundation of Jiangsu Province [BK20161441]
- Six Talent Peaks Project of Jiangsu Provinc [SWYY-007]
- Nanjing Municipal General Project for the Development of Medical Science and Technology [YKK16273]
Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120-catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Here, we show that p120ctn in exosomes secreted from liver cancer cells suppresses HCC cell proliferation and metastasis and expansion of liver cancer stem cells (CSCs). Mechanically, exosome p120ctn inhibits HCC cell progression via the STAT3 pathway, and the STAT3 inhibitor S3I-201 abolishes the observed effects on growth, metastasis, and self-renewal ability between exosome p120ctn-treated HCC cells and control cells. Taken together, we propose that p120ctn-containing exosomes derived from cancer cells inhibit the progression of liver cancer and may offer a new therapeutic strategy.
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