期刊
MICROCHIMICA ACTA
卷 186, 期 6, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-019-3438-1
关键词
Au NC; Aggregation-induced emission enhancement; HepG2 cell imaging
资金
- National Natural Science Foundation of China [21575048, 21775052, 81671742]
- Science and Technology Development project of Jilin province, China [20180414013GH]
A turn-on fluorometric method is described for selective and sensitive detection of cysteine (Cys). Gold nanoclusters (Au NCs) capped with glutathione (GSH) are used as afluorescent probe. If Ce3+ ion are present, they will bind to the carboxy groups of theGSH-capped Au NC. This results in aggregation-induced emission enhancement (AIEE), best measured at excitation/emission wavelengths of 360/575nm. On addition of Cys, which has less steric hindrance compared with GSHand higher affinity for Ce3+, it will bind toCe(3+) through the carboxyl group and link with Au NCs via Au-S bond. Hence, the AIEE is increased and Cys can be quantified via this effect with a linear response in the 0.4-120molL(-1) Cys concentration range and a detection limit of 0.15molL(-1).
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