期刊
MICROBIOLOGY-SGM
卷 165, 期 8, 页码 819-833出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000808
关键词
Listeria monocytogenes; sigma B; PrfA; virulence; light-sensing
类别
资金
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [721456]
- Swedish Research Council [2016-03313]
- K. A. Wallenberg Foundation
- Wenner-Gren Foundations
- Umea University
- Stiftelsen Olle Engkvist Byggmastare
- ERC [260764-RNAntibiotics]
- Swedish Research Council [2016-03313] Funding Source: Swedish Research Council
- Vinnova [2016-03313] Funding Source: Vinnova
In contrast to obligate intracellular pathogens that can remain in relatively stable host-associated environments, the soil-living bacterial pathogen Listeria monocytogenes has to sense and respond to physical and chemical cues in a variety of quite different niches. In particular, the bacterium has to survive the dramatic transition from its saprophytic existence to life within the host where nutritional stress, increased temperature, acidity, osmotic stress and the host defences present a new and challenging landscape. This review focuses on the sB and PrfA regulatory systems used by L. monocytogenes to sense the changing environment and implement survival mechanisms that help to overcome the disparate conditions within the host, but also to switch from a harmless saprophyte to an impressively effective pathogen.
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