期刊
MEDICAL MYCOLOGY
卷 58, 期 3, 页码 404-407出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myz057
关键词
Candida auris; biofilm; synergy; farnesol; lock therapy
资金
- New National Excellence Program of the Ministry of Human Capacities [EFOP-3.6.3-VEKOP-16-2017-00009, UNKP-18-3]
Candida auris biofilms exhibit decreased susceptibility to echinocandins, which is associated with poorer clinical outcomes. Farnesol is a quorum-sensing molecule enhancing the activity of antifungals; therefore, we evaluated the in vitro effect of farnesol with anidulafungin, caspofungin, or micafungin against biofilms using fractional inhibitory concentration indexes (FICI), Bliss independence model, LIVE/DEAD-assay and scanning electron microscopy. Based on mathematical models, farnesol caused synergism in eleven out of twelve cases (FICIs range 0.133-0.507; Bliss synergy volume range 70.39-204.6 mu M-2%). This was confirmed by microscope images of combination-exposed biofilms. Our study showed the prominent effect of farnesol with echinocandins against C. auris biofilms.
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