期刊
MATERIALS TODAY
卷 28, 期 -, 页码 10-16出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mattod.2019.04.022
关键词
Motors; Swimmers; Vertical motion; pH-responsive; Metal-organic frameworks
资金
- Australia National Health and Medical Research Council (NHMRC) [APP1163786]
- UNSW
- Australian Research Council (ARC) [DP190101008]
- Australian Government Research Training Program Scholarship
- MCTL Visiting Fellowship Program
Self-propelled chemical motors have found vast promise for applications from nanomedicine to environmental remediation. However, strategies for controlling their directional motion on demand still represents one of the major challenges for the development of smart motor systems to be realized in real-world applications. Here, we report for the first time the design of a novel submarine-like micromotor that is capable of directional vertical motion on centimeter scale by pH-regulated buoyancy control. With the aid of a pH-responsive, hydrophilic/hydrophobic phase-shifting polymer, gas bubbles produced by the biocatalytic metal-organic framework micromotors can be reversibly retained/expelled from the micromotors, leading to the buoyancy-controlled ascending or descending vertical motion. Importantly, anti-cancer drug-loaded micromotors showed directional cytotoxicity to three-dimensional cell cultures, depending on the pH of the cellular environment. We expect this study will open up new avenues for designing directional propulsion mechanisms for chemical motors, showing potential as autonomous robotics for in vivo delivery in complex biological environments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据