期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 98, 期 -, 页码 649-656出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.01.019
关键词
Antibacterial; Chitosan; Catechol; Silver nanoparticles; Titanium
资金
- National Key RAMP
- D Program of China [2017YFC1600900]
- National Natural Science Foundation of China [21504072, 51741304]
- Fundamental Research Funds for the Central Universities [YJ201626, SWU115005, XDJK2018B006]
- Sichuan University Research Fund for Full-Time Postdoctoral [2018SCU12056]
The titanium (Ti) and its alloys have been widely used for dental and orthopedic implants. However, the Ti-based implants may suffer from bacterial infection, which would result in insufficient healing, implant failure and repeated surgical intervention. It is of great interest to inhibit the bacterial adhesion and colonization on the Ti-based implants by introducing proper surface coatings. In this work, a simple method was employed to synthesize the water-soluble catechol-containing chitosan (CACS). The CACS coatings can be deposited onto various substrate surfaces and exhibit substrate-independent behavior. The CACS-coated Ti surfaces were further deposited with silver nanoparticles (Ag NPs) via in-situ reduction of Ag+ ions using catechol moieties as the reducing agents. The resulting AgNPs/CACS-coated Ti surfaces exhibit antibacterial properties and can prevent the surface adhesion of bacterial cells, as evidenced by the inhibition zone test, live/dead bacterial staining assay and spread plate method. In addition, they show negligible cytotoxicity to L929 mouse fibroblast cells.
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