期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 98, 期 -, 页码 311-323出版社
ELSEVIER
DOI: 10.1016/j.msec.2018.12.148
关键词
Hydroxyapatite; Biocompatible; Non-cytotoxic; Tumor-cell targeting; Controlled drug delivery; Superparamagnetic
资金
- National Research Foundation of Korea (NRF)
- NRF fund [2017R1A2B4003578, 2016R1D1A1B03933216, 20181D1A1B07049883]
- Chungnam National University Fund
- National Research Foundation of Korea [2016R1D1A1B03933216, 2017R1A2B4003578] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Diagnosis of cancer by chemotherapy treatment, severe side effects caused by high dosages of cancer drugs include non-controlled cytotoxicity to bone marrow cells and immune cells. To overcome, we have synthesized nanoparticles with controlled sized hydroxyapatite (nHAp) materials doped and co-doped with silver and iron by co-precipitation, yielding materials that can treat both the infections and malignant tumors with non-cytotoxic nature to normal cells. Spherical and rod like morphologies were observed for the samples with higher Ag+ doping concentrations with average size of 50 +/- 5 nm and (75 x 22) +/- 5 nm(2), whereas higher Ag+/Fe2+ co-doping concentrations yielded samples with spherical, rod-like, and flake-like structures. For samples nHAp and Ag+-nHAp samples were diamagnetic, whereas the Fe2+-nHAp and Ag+/Fe2+ co-doped samples were super-paramagnetic. The in vitro biological toxicity study revealed that the Ag+/Fe2+-nHAp nanoparticles are effective for targeting to kill cancerous cells, for example, human cervical cancer (HeLa) cells efficiently while they are non-toxic to normal cells. Applying these nanoparticles for drug delivery system, 5-fluorouracil was loaded in the nanoparticles and studied its release kinetics. In the case of Ag+/Fe2+ co-doped nHAp samples, a pulsatile drug release profile was observed, which the drug was released for about a week on varying the Ag+ and Fe2+ concentrations. The 5-fluorouracil release kinetics was well fitted by the first-order model with diffusion. Thus, nHAps co-doped with Ag+/Fe2+ material have the potential to lag the time on delivering the drug at site-specific could be with an application in biomedicine such as to treat malignant tumor without any bacterial side effect.
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