期刊
MARINE DRUGS
卷 17, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/md17050278
关键词
natural products; ascidians; Polycarpa aurata; 1; 2; 4-thiadiazole alkaloids; Schistoma mansoni
资金
- Ministero dell'Istruzione, dell' Universita e della Ricerca (MIUR), PRIN Projects [2010C2LKKJ_006, 20154JRJPP_004]
- Regione Campania-POR Campania FESR 2014/2020 Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie-Campania Oncoterapie [B61G18000470007]
A deep study of the metabolic content of the tunicate Polycarpa aurata, collected from Indonesian coast, afforded the isolation of two novel alkaloids, polyaurines A (1) and B (2), along with two new p-substituted benzoyl derivatives (3 and 4) and four known compounds (5-8). The structural elucidation of the new secondary metabolites was assigned by 1D, 2D NMR, and HRESIMS techniques. Computational studies resulted a useful tool to unambiguously determine in polyaurine B the presence of rarely found 1,2,4-thiadiazole ring. The effects of polyaurines A and B on mammalian cells growth and on the viability of different blood-dwelling Schistosoma mansoni (phylum: Platyhelminthes) stages, as well as egg production, were evaluated. Both compounds resulted not cytotoxic; interestingly some of the eggs produced by polyaurine A-treated adult pairs in vitro are smaller, deformed, and/or fragmented; therefore, polyaurine A could represent an interesting bioactive natural molecule to be further investigated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据