期刊
MARINE DRUGS
卷 17, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/md17050262
关键词
marine-derived fungus; Aspergillus versicolor; diketopiperazine; antibacterial
资金
- National Key R&D Program of China [2018YFC0311002, 2017YFD0201203, 2017YFC1601300, 2017YFE0108200]
- National Natural Science Foundation of China [31600136, 31430002, 31720103901]
- Fundamental Research Funds for the Central PublicWelfare Research Institutes [Z0547]
- Taishan Scholarship
- Fundamental Research Funds for the Central Universities [22221818014]
Six new diketopiperazines, (+/-)-7,8-epoxy-brevianamide Q ((+/-)-1), (+/-)-8-hydroxy-brevianamide R ((+/-)-2), and (+/-)-8-epihydroxy-brevianamide R ((+/-)-3), together with four known compounds, (+/-)-brevianamide R ((+/-)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guerin. Compounds 1-4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据