期刊
MARINE DRUGS
卷 17, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/md17050253
关键词
Chaetomium globosum; azaphilone alkaloids; cytotoxicity; deep-sea-derived fungus
资金
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2016ASKJ05-04, 2016ASKJ08-02]
- National Natural Science Foundation of China [41606166]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- Shandong Provincial Natural Science Fund [ZR2016BQ37]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Fundamental Research Funds for the Central Universities [201941001]
- Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) [2018SDKJ0401-2]
- Taishan Scholar Youth Expert Program in Shandong Province [tsqn201812021]
- China Postdoctoral Science Foundation [2017M622286]
- Qingdao Postdoctoral Applied Research Project - Qingdao Municipal Bureau of Human Resource and Social Security
Three new azaphilone alkaloids containing glutamine residues, namely N-glutarylchaetoviridins A-C (1-3), together with two related compounds (4 and 5) were isolated from the extract of Chaetomium globosum HDN151398, a fungus isolated from a deep-sea sediment sample collected in South China Sea. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESIMS spectroscopic data and chemical analysis. N-glutarylchaetoviridins A-C (1-3) represent the first class of chaetoviridins characterized by embedded glutamate residues. Amino acids incubation experiments produced five azaphilone laden different amino acids residues (6-10) which indicated that this method can enhanced the structural diversity of this strain by culturing with amino acids. Cytotoxicity of the isolated compounds were evaluated against a panel of human cancer cell lines.
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