期刊
LWT-FOOD SCIENCE AND TECHNOLOGY
卷 105, 期 -, 页码 200-205出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.lwt.2019.02.043
关键词
Salmonellosis; Probiotic; Preventive; Mechanism
资金
- National Natural Science Foundation of China [31470161, 31530056, JUFSTR20180102]
- collaborative innovation center of food safety and quality control in Jiangsu Province
Salmonellosis is one of the world's most leading epidemic diseases and poses a great threat to public health. Probiotic administration is an effective strategy to cope with pathogenic infections with few side-effects and a high safety profile. Lactobacillus plantarum ST-III is a probiotic with reported cholesterol-lowering activity. In this study, we investigated the preventive effects of L. plantar= ST-III against Salmonella infection in a mouse model. L. plantar= ST III pretreatment significantly decreased the lethal effect of Salmonella. Further studies showed that several mechanisms are involved in this preventive effect, including (1) inhibition of the growth of Salmonella; (2) enhancement of intestinal barrier functions to defend against Salmonella invasion; (3) promotion of the Th1 response to deter systemic spread; and (4) induction of anti-inflammatory effects during infection. Our results suggest that L. plantarum ST-III has great potential to control the prevalence of food-borne pathogens as supplement in functional food products.
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