期刊
JOURNAL OF THE ROYAL SOCIETY INTERFACE
卷 16, 期 154, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsif.2018.0887
关键词
gene expression; intracellular competition; finite resources; computational and mathematical models; synthetic biology; systems biology
资金
- Israeli Ministry of Science, Space and Technology
- Ela Kodesz Institute for Medical Physics and Engineering
Dissecting the competition between genes for shared expressional resources is of fundamental importance for understanding the interplay between cellular components. Owing to the relationship between gene expression and cellular fitness, genomes are shaped by evolution to improve resource allocation. Whereas experimental approaches to investigate intracellular competition require technical resources and human expertise, computational models and in silico simulations allow vast numbers of experiments to be carried out and controlled easily, and with significantly reduced costs. Thus, modelling competition has a pivotal role in understanding the effects of competition on the biophysics of the cell. In this article, we review various computational models proposed to describe the different types of competition during gene expression. We also present relevant synthetic biology experiments and their biotechnological implications, and discuss the open questions in the field.
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