期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 400, 期 -, 页码 72-82出版社
ELSEVIER
DOI: 10.1016/j.jns.2019.03.015
关键词
Autophagy; Neurons; Cerebral ischemic injury; Apoptosis; Regulators
资金
- Priority Academic Program Development of Jiangsu Higher Education Institutions [BY2015072-03]
- Policy Directive Program of Jiangsu Province [BY2015072-03]
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2016ZX09101031]
There is increasing evidence indicating that autophagy may be a new target in the treatment of ischemic stroke. Moderate autophagy can clear damaged organelles, thereby protecting cells against various injuries. However, long-term excessive autophagy brings redundant degradation of cell contents, leading to cell death and eventually serious damage to tissues and organs. A number of different animal models of ischemic brain injury shows that autophagy is activated and involved in the regulation of neuronal death during ischemic brain injury. This article summarizes the role of autophagy, its underlying regulators and mechanisms in ischemic neuronal injury. We briefly introduce the relationship between apoptosis and autophagy and give a summary of research methods and modulators of autophagy.
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