期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 400, 期 -, 页码 15-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2019.03.001
关键词
Neurography; MRI; Microneurography; Micro; CIDP; Relaxometry; Quantitative; Nerve
Objective: In this study we investigated the potential of magnetic resonance (MR) micro-neurography to detect morphological and relaxometric changes in distal tibial nerves in patients affected with chronic inflammatory demyelinating polyneuropathy (CIDP), and their associations with clinical and electrophysiological features. Materials and methods: 10 subjects affected with CIDP and 10 healthy subjects were examined. Multiple MR parameters, including the number of fascicles (N), fascicles diameter (FD), total fascicles area (FA), epineurium area (EA), total nerve area (NA), fascicles to nerve ratio (FNR) and quantitative T2 and proton density (PD) were investigated on high resolution MR images of the distal tibial nerve. Those parameters were correlated with clinical scores, age of onset, disease duration and electrophysiologic data. Results: Median NA and FA were significantly increased in the CIDP population (median values for NA in cm(2) in CIDP: 0.185; controls: 0.135; p: 0.028; for FA in CIDP 0.136; controls 0.094; p: 0.021). There was no correlation between the parameters investigated and clinical or electrophysiologic features. Conclusion: MR microneurography can detect increased total nerve and fascicle area in distal tibial nerves in CIDP and may be useful for diagnosing CIDP.
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