期刊
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
卷 82, 期 5, 页码 343-350出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JCMA.0000000000000094
关键词
Asthma; CC chemokine ligand 2 (CCL2); Signaling pathway; Sonic hedgehog (Shh)
资金
- National Natural Science Foundation of China [81070008, 81170016, 81470214]
- Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents
Asthma is a chronic inflammatory disease of the airways in which many cells are involved, including mast cells, eosinophils. T lymphocytes, and so on. During the process, many chemokines and mediators are released to engage in recruiting and activating eosinophils and other inflammatory cells. Also, some signaling pathways are involved in the pathobiology of asthma. Sonic hedgehog (Shh) is one of the members of hedgehog gene families. Shh signaling plays a critical role in the embryonic development, including the lung. Previous findings from our team reveal that Shh is involved in the asthma pathogenesis. Recombinant Shh could induce the CC chemokine ligand 2 (CCL2) overexpressing and Smo inhibitor GDC-O449 could inhibit CCL2 expression in airway epithelial cells, monocytes, or macrophages. Hence, we reviewed the effects of Shh and CCL2 signaling pathways, and the interaction between signaling pathways in asthma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据