期刊
COUNTERMEASURES AGAINST CHEMICAL THREATS
卷 1374, 期 -, 页码 78-85出版社
BLACKWELL SCIENCE PUBL
DOI: 10.1111/nyas.13059
关键词
HSP70; HSP72; oxidative stress; apoptosis inhibitor; medical countermeasure; reperfusion therapy
类别
资金
- NIEHS NIH HHS [R21 ES024028] Funding Source: Medline
Heat shock protein 72 (HSP72) is perhaps the most important member of the HSP70 family of proteins, given that it is induced in a wide variety of tissues and cells to combat stress, particularly oxidative stress. Here, we review independent observations of the critical role this protein plays as a pulmonary cytoprotectant and discuss the merits of developing HSP72 as a therapeutic for rapid delivery to cells and tissues after a traumatic event. We also discuss the fusion of HSP72 to a cell-penetrating single-chain Fv antibody fragment derived from mAb 3E10, referred to as Fv-HSP70. This fusion construct has been validated in vivo in a cerebral infarction model and is currently in testing as a clinical therapeutic to treat ischemic events and as a fieldable medical countermeasure to treat inhalation of toxicants caused by terrorist actions or industrial accidents.
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