期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 21, 页码 8436-8440出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04175
关键词
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资金
- NIH NIGMS [R01 GM102358]
- NIH [NSF CHE0421224, CHE0840401, CHE1229234, CHE1048367, NIH S10 OD016267-01, S10 RR026962-01, P20GM104316, P30GM110758]
- University of Delaware (UD)
- University of Delaware Research Foundation
- Research Corp. Cottrell Scholars Program
A general catalytic method for asymmetric C-alkylation of nitroalkanes using nickel catalysis is described. This method enables the formation of highly enantioenriched beta-nitroamides from readily available alpha-bromoamides using mild reaction conditions that are compatible with a wide range of functional groups. When combined with subsequent reactions, this method allows access to highly enantioenriched products with nitrogen bearing fully substituted carbon centers.
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