期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 20, 页码 8110-8115出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04332
关键词
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资金
- NSFC [21425205, 21672067, 21801078]
- 973 Program [2015CB856600]
- Program of Eastern Scholar at Shanghai Institutions of Higher Learning
A highly enantioselective palladium-catalyzed iodine atom transfer cycloisomerization of unactivated alkenes has been developed. This represents the first example of highly enantioselective carboiodination of olefin-tethered aryl iodides, which provides a perfect atom economy method to construct a series of optically active 2,3-dihydrobenzofuran, indolines and chromane bearing an alkyl iodide group in moderate to good yields. Moreover, the use of readily available starting materials, a broad substrate scope, high selectivity, mild reaction conditions, as well as versatile transformation of the product make this approach attractive. The mechanism of this Pd(0)-catalyzed asymmetric carboiodination of alkenes has been investigated with density functional theory.
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