4.8 Article

Palladium/XuPhos-Catalyzed Enantioselective Carboiodination of Olefin-Tethered Aryl Iodides

期刊

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 20, 页码 8110-8115

出版社

AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04332

关键词

-

资金

  1. NSFC [21425205, 21672067, 21801078]
  2. 973 Program [2015CB856600]
  3. Program of Eastern Scholar at Shanghai Institutions of Higher Learning

向作者/读者索取更多资源

A highly enantioselective palladium-catalyzed iodine atom transfer cycloisomerization of unactivated alkenes has been developed. This represents the first example of highly enantioselective carboiodination of olefin-tethered aryl iodides, which provides a perfect atom economy method to construct a series of optically active 2,3-dihydrobenzofuran, indolines and chromane bearing an alkyl iodide group in moderate to good yields. Moreover, the use of readily available starting materials, a broad substrate scope, high selectivity, mild reaction conditions, as well as versatile transformation of the product make this approach attractive. The mechanism of this Pd(0)-catalyzed asymmetric carboiodination of alkenes has been investigated with density functional theory.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据