期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 20, 页码 8104-8109出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04189
关键词
-
资金
- National Institutes of Health [GM120281]
- National Science Foundation [CHE-1663779]
Due to the great value of amino alcohols, new methods for their synthesis are in high demand. Abundant aliphatic alcohols represent the ideal feedstock for the method development toward this important motif. To date, transition-metal-catalyzed approaches for the directed remote amination of alcohols have been well established. Yet, they have certain disadvantages such as the use of expensive catalysts and limited scope. Very recently, transition-metal-free visible-light-induced radical approaches have emerged as new powerful tools for directed remote amination of alcohols. Relying on 1,5-HAT reactivity, these methods are limited to beta- or delta-amination only. Herein, we report a novel transition-metal-and visible-light-free room-temperature radical approach for remote beta-, gamma-, and delta-C(sp(3))-N bond formation in aliphatic alcohols using mild basic conditions and readily available diazonium salt reagents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据