期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 17, 页码 6859-6863出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b03029
关键词
-
资金
- National Cancer Institute [U01-CA198989, 1R01CA216436]
- University of Chicago Medicine Comprehensive Cancer Center [NIH CCSG: P30 CA014599]
With tunability and porosity, nanoscale metal-organic frameworks (nMOFs) can incorporate multiple components to realize complex functions for biomedical applications. Here we report the synthesis of W-18@Hf-12-DBB-Ir, a new nMOF assembly hierarchically incorporating three high-Z components-Hf-based metal-oxo clusters, Ir-based bridging ligands, and W-based polyoxometalates (POMs)-as a multifarious radio-enhancer. Cationic Hf-12-DBB-Ir was built from Hf-12 secondary building units (SBUs) and [Ir(bpy)(2)(ppy)](+)(bpy = 2,2'-bipyridine, ppy = 2-phenylpyridine) derived dicarboxylate ligands (DBB-Ir) and then loaded with Wells-Dawson-type [P2W18O62](6-) (W-18) POMs to afford W-18@Hf-12-DBB-Ir. Upon X-ray irradiation, W-18@Hf-12-DBB-Ir significantly enhances hydroxyl radical generation from Hf-12 SBUs, singlet oxygen generation from DBB-Ir ligands, and superoxide generation from W-18 POMs, respectively. Through synergistic cell killing by these distinct reactive oxygen species, W-18@Hf-12-DBB-Ir elicited superb anticancer efficacy with >98% tumor regression at a low X-ray dose of 5 x 1 Gy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据