期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 17, 页码 6864-6868出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b03113
关键词
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资金
- Robert A. Welch Foundation [F-0038]
- NIH-NIGMS [RO1-GM069445]
- Eli Lilly and Company
A regiodivergent catalytic method for direct conversion of aldehydes to branched or linear alkyl ketones is described. Rhodium complexes modified by (PBuMe)-Bu-t-Me-2 catalyze formate-mediated aldehyde-vinyl bromide reductive coupling-redox isomerization to form branched ketones. Use of the less strongly coordinating ligand, PPh3, promotes vinyl- to allylrhodium isomerization en route to linear ketones. This method bypasses the 3-step sequence often used to convert aldehydes to ketones involving the addition of pre-metalated reagents to Weinreb or morpholine amides.
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