期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 22, 页码 8778-8782出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04325
关键词
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资金
- NIH-NIGMS [R01GM101389]
Cyclic imines, generated in situ from their corresponding N-lithiated amines and a ketone hydride acceptor, undergo reactions with a range of organometallic nucleophiles to generate alpha-functionalized amines in a single operation. Activation of the transient imines by Lewis acids that are compatible with the presence of lithium alkoxides was found to be crucial to accommodate a broad range of nucleophiles including lithium acetylides, Grignard reagents, and aryllithiums with attenuated reactivities.
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