期刊
ANNALS OF SURGICAL ONCOLOGY
卷 24, 期 5, 页码 1435-1442出版社
SPRINGER
DOI: 10.1245/s10434-016-5702-5
关键词
-
资金
- National Key Projects for Infectious Diseases of China [2012ZX10002012-007, 2016ZX10002018-008]
- National Natural Science Foundation of China [31270863, 81402082, 81402085, 81471621, 81472227, 81671628]
- Program for New Century Excellent Talents in University [NCET-13-0146]
- Shanghai Municipal Natural Science Foundation [16ZR1406500]
- Shanghai Municipal Commission of Health and Family Planning Program [20144Y0223]
- Innovation Project of Shanghai Jiao Tong University School of Medicine [16XJ21001, 16XJ21003]
The role played by the innate immune system in determining the clinical outcome of clear-cell renal cell carcinoma (ccRCC) was still blurred. This study was designed to investigate the prognostic significance of tumor infiltrating mast cells (TIMs) in ccRCC. The study retrospectively enrolled a training set (474 patients) and a validation set (188 patients) with nonmetastasis (pT1-4N0M0) ccRCC from two institutional medical centers of China. TIMs was evaluated by immunohistochemical staining of tryptase and its association with clinicopathologic features and prognosis were evaluated. In ccRCC tissues, TIMs ranged from 0 to 103 cells/mm(2) and 0 to 113 cells/mm(2) in the training set and validation set, respectively. TIMs was negatively correlated with tumor size (P < 0.001 and P < 0.001, respectively), pathological T stage (P = 0.005 and P = 0.007, respectively) and Fuhrman grade (P < 0.001 and P < 0.001, respectively). Patients with abundant TIMs infiltration showed significantly longer cancer-specific survival in the training cohort and the validation cohort (P < 0.001 and P < 0.001). Patients with abundant mast cell infiltration showed significantly longer overall survival in the TCGA cohort (P < 0.001). Moreover, multivariate analysis identified TIMs as an independent prognostic factor for cancer-specific survival (CSS) and relapse-free survival (RFS). Also, TIMs was significantly correlated with CSS and RFS of the mediate and high-risk patients in the training cohort and the validation cohort. TIMs density is a powerful independent prognostic factor for CSS and RFS in patients with nonmetastasis (pT1-4N0M0) ccRCC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据